Ontology highlight
ABSTRACT:
SUBMITTER: Sarvestani SK
PROVIDER: S-EPMC7801686 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Sarvestani Samaneh K SK Signs Steven S Hu Bo B Yeu Yunku Y Feng Hao H Ni Ying Y Hill David R DR Fisher Robert C RC Ferrandon Sylvain S DeHaan Reece K RK Stiene Jennifer J Cruise Michael M Hwang Tae Hyun TH Shen Xiling X Spence Jason R JR Huang Emina H EH
Nature communications 20210111 1
The pathogenesis of ulcerative colitis (UC), a major type of inflammatory bowel disease, remains unknown. No model exists that adequately recapitulates the complexity of clinical UC. Here, we take advantage of induced pluripotent stem cells (iPSCs) to develop an induced human UC-derived organoid (iHUCO) model and compared it with the induced human normal organoid model (iHNO). Notably, iHUCOs recapitulated histological and functional features of primary colitic tissues, including the absence of ...[more]