NOD2 deficiency increases retrograde transport of secretory IgA complexes in Crohn's disease.
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ABSTRACT:
SUBMITTER: Rochereau N
PROVIDER: S-EPMC7801705 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
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NOD2 deficiency increases retrograde transport of secretory IgA complexes in Crohn's disease.
Rochereau Nicolas N Roblin Xavier X Michaud Eva E Gayet Rémi R Chanut Blandine B Jospin Fabienne F Corthésy Blaise B Paul Stéphane S
Nature communications 20210111 1
Intestinal microfold cells are the primary pathway for translocation of secretory IgA (SIgA)-pathogen complexes to gut-associated lymphoid tissue. Uptake of SIgA/commensals complexes is important for priming adaptive immunity in the mucosa. This study aims to explore the effect of SIgA retrograde transport of immune complexes in Crohn's disease (CD). Here we report a significant increase of SIgA transport in CD patients with NOD2-mutation compared to CD patients without NOD2 mutation and/or heal ...[more]
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