Dataset Information
Identification of novel prognostic biomarkers in renal cell carcinoma.
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ABSTRACT: Objective
To identify novel prognostic biomarkers in renal cell carcinoma (RCC).Results
12 coding genes and one miRNA were finally identified as prognostic biomarkers. All of them were related to a poor prognosis. Lower expression levels of the coding genes were observed in higher clinical stages. Prognostic signatures including 7 biomarkers were identified. Patients in the high-risk group had worse survival than those in the low-risk group. The areas under the curves in different years indicated that it was a valuable signature in prognosis. It was found that elevated WDR72 inhibited the survival and invasion of 786-O and 769P cells in vitro.Conclusions
Thirteen prognostic biomarkers of RCC were identified. Among them, 7 biomarkers comprised a signature to evaluate the RCC prognosis. WDR72 was a cancer suppressor and a potential therapeutic target in RCC.Methods
Differentially expressed genes/miRNAs (DEGs/DEMs) and prognosis-related genes/miRNAs were acquired from public database. Prognostic biomarkers were identified by overlapping the significant DEGs/DEMs and prognosis-related genes/miRNAs. The associations between these biomarkers and the clinical stages were analyzed. All of these prognostic biomarkers were further investigated with multi-variable Cox regression. Finally, the inhibitory effect of WDR72 on the growth and invasion of RCC cells was studied.
SUBMITTER: Zou Y
PROVIDER: S-EPMC7803519 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Publications
Identification of novel prognostic biomarkers in renal cell carcinoma.
Aging 20201121 24
<h4>Objective</h4>To identify novel prognostic biomarkers in renal cell carcinoma (RCC).<h4>Results</h4>12 coding genes and one miRNA were finally identified as prognostic biomarkers. All of them were related to a poor prognosis. Lower expression levels of the coding genes were observed in higher clinical stages. Prognostic signatures including 7 biomarkers were identified. Patients in the high-risk group had worse survival than those in the low-risk group. The areas under the curves in differen ...[more]