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Cerebellar-limbic neurocircuit is the novel biosignature of physio-cognitive decline syndrome.

ABSTRACT: Both physical and cognitive deficits occur in the aging process. We operationally defined the phenomenon as physio-cognitive decline syndrome (PCDS) and aimed to decipher its corresponding neuroanatomy patterns and neurocircuit. High resolution 3T brain magnetic resonance imaging (MRI) images from a community-dwelling longitudinal aging cohort were analysed. PCDS was defined as weakness (handgrip strength) and/or slowness (gait speed) concomitant with impairment in any cognitive domain (defined by 1.5 standard deviation below age, sex-matched norms), but without dementia or disability. Among 1196 eligible ? 50-year-old (62±9 years, 47.6%men) subjects, 15.9% had PCDS. Compared to the other participants, individuals with PCDS had significantly lower gray-matter volume (GMV) in the bilateral amygdala and thalamus, right hippocampus, right temporo-occipital cortex, and left cerebellum VI and V regions. The regions of reduced GMV in people with PCDS were similar between the middle-aged and older adults; whereas larger clusters with more extensive GMV-depleted regions were observed in ?65-year-olds with PCDS. Diffusion-weighted tractography showed disrupted hippocampus-amygdala-cerebellum connections in subjects with PCDS. The neuroanatomic characteristics revealed by this study provide evidence for pathophysiological processes associated with concomitant physio-cognitive decline in the elderly. This neurocircuit might constitute a target for future preventive interventions.

SUBMITTER: Liu LK

PROVIDER: S-EPMC7803525 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature

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Cerebellar-limbic neurocircuit is the novel biosignature of physio-cognitive decline syndrome.

Liu Li-Kuo LK Chou Kun-Hsien KH Hsu Chih-Chin Heather CH Peng Li-Ning LN Lee Wei-Ju WJ Chen Wei-Ta WT Lin Ching-Po CP Chung Chih-Ping CP Wang Pei-Ning PN Chen Liang-Kung LK

Aging 20201125 24

Both physical and cognitive deficits occur in the aging process. We operationally defined the phenomenon as physio-cognitive decline syndrome (PCDS) and aimed to decipher its corresponding neuroanatomy patterns and neurocircuit. High resolution 3T brain magnetic resonance imaging (MRI) images from a community-dwelling longitudinal aging cohort were analysed. PCDS was defined as weakness (handgrip strength) and/or slowness (gait speed) concomitant with impairment in any cognitive domain (defined ...[more]

PMID: 33234736

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Dataset Information

Cerebellar-limbic neurocircuit is the novel biosignature of physio-cognitive decline syndrome.

Publications

Cerebellar-limbic neurocircuit is the novel biosignature of physio-cognitive decline syndrome.

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