Dataset Information

Determinants of Bacille Calmette-Guerin scarification in Danish children.

ABSTRACT:

Background

Studies in low-income countries have shown that among Bacille Calmette-Guérin (BCG) vaccinated children, those who develop a BCG-scar have significantly better survival than those who do not develop a scar. In a Danish multicenter randomized clinical trial we assessed determinants for developing a BCG-scar and for BCG scar size following neonatal BCG vaccination.

Methods

At three Danish hospitals, newborns were randomized 1:1 to BCG vaccination or no BCG vaccination. The infants were invited for a clinical examination at the ages of 3 and 13 months. At 13 months, the scar site was inspected and scar size measured. We investigated three groups of determinants; external, parental, and individual-level determinants on relative scar prevalence and differences in median scar sizes.

Results

Among 2118 BCG vaccinated infants, 2039 (96 %) were examined at 13 months; 1857 of these (91 %) had developed a BCG-scar. Compared with Copenhagen University Hospital, Hvidovre (85 %), Copenhagen University Hospital, Rigshospitalet had a scar prevalence of 95 % (adjusted Prevalence ratio (aPR) = 1.24 [CI 95 %: 1.18 to 1.30]); it was 93 % at Kolding Hospital (aPR 1.27 [CI 95 %: 1.19 to 1.35]). Increasing vaccine experience was positively associated with developing a scar and with scar size.

Conclusion

Across multiple potential determinants of BCG scaring and size, logistical factors dominated. The results support that injection technique is an important determinant of developing a scar. Given the strong link between having a BCG scar and subsequent health, improved BCG vaccination technique could play a major role for child health.

SUBMITTER: Jensen TM

PROVIDER: S-EPMC7803645 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature

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Publications

Determinants of Bacille Calmette-Guérin scarification in Danish children.

Jensen Trine Mølbæk TM Jensen Signe Kjeldgaard SK Birk Nina Marie NM Rieckmann Andreas A Hoffmann Thomas T Benn Christine Stabell CS Jeppesen Dorthe Lisbeth DL Pryds Ole O Nissen Thomas Nørrelykke TN

Heliyon 20210104 1

<h4>Background</h4>Studies in low-income countries have shown that among Bacille Calmette-Guérin (BCG) vaccinated children, those who develop a BCG-scar have significantly better survival than those who do not develop a scar. In a Danish multicenter randomized clinical trial we assessed determinants for developing a BCG-scar and for BCG scar size following neonatal BCG vaccination.<h4>Methods</h4>At three Danish hospitals, newborns were randomized 1:1 to BCG vaccination or no BCG vaccination. Th ...[more]

PMID: 33474505

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