Ontology highlight
ABSTRACT:
SUBMITTER: Wang H
PROVIDER: S-EPMC7803730 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Nature communications 20210112 1
The transmembrane P-glycoprotein (P-gp) pumps that efflux drugs are a major mechanism of cancer drug resistance. They are also important in protecting normal tissue cells from poisonous xenobiotics and endogenous metabolites. Here, we report a fucoidan-decorated silica-carbon nano-onion (FSCNO) hybrid nanoparticle that targets tumor vasculature to specifically release P-gp inhibitor and anticancer drug into tumor cells. The tumor vasculature targeting capability of the nanoparticle is demonstrat ...[more]