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Increased risk of major depressive disorder in sleep apnea patients in Taiwan.


ABSTRACT: The association between sleep apnea (SA) and depression had been reported in a few previous studies. However, whether SA increases the risk of major depressive disorder (MDD) has not been studied comprehensively in a large-scale study. We performed this population-based cohort study to assess the association between SA and MDD. We identified adult patients having SA from the Taiwan National Health Insurance Research Database and excluded those having MDD before SA diagnosis. Thirty control subjects were randomly selected to match to each SA patient by age and sex. Totally, 10,259 SA patients were matched to 102,590 control subjects. The incidence rate and cumulative incidence of MDD were significantly higher in SA patients than in the control subjects (both p?

SUBMITTER: Chen CM 

PROVIDER: S-EPMC7803988 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature

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Increased risk of major depressive disorder in sleep apnea patients in Taiwan.

Chen Chia-Min CM   Kuo Chia-Yu CY   Wu Meng-Ni MN   Hung Jen-Yu JY   Hsu Chung-Yao CY   Tsai Ming-Ju MJ  

Scientific reports 20210112 1


The association between sleep apnea (SA) and depression had been reported in a few previous studies. However, whether SA increases the risk of major depressive disorder (MDD) has not been studied comprehensively in a large-scale study. We performed this population-based cohort study to assess the association between SA and MDD. We identified adult patients having SA from the Taiwan National Health Insurance Research Database and excluded those having MDD before SA diagnosis. Thirty control subje  ...[more]

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