A pre-operative prognostic score for the selection of patients for salvage surgery after recurrent head and neck squamous cell carcinomas.

ABSTRACT: Salvage surgery in recurrent head and neck squamous cell carcinoma has a poor outcome, both in terms of survival and quality of life. Therefore, the identification of pre-operative prognostic factors to improve the selection of patients who could benefit the most from salvage surgery is clinically relevant. The present study is a single-center retrospective analysis of 164 patients treated with salvage surgery after recurrence of head and neck cancer. Progression free survival and overall survival were calculated through Kaplan-Meier method. Hazard risk (HR) and corresponding confidence intervals (CI) were estimated through Cox proportional hazard model, adjusting for potential confounders. Significant predictors were combined into a prognostic score, attributing one point to each factor. Progression-free survival and overall survival were respectively 50.3% and 56.5% at 2 years, and 36.6% and 44.2% at 5 years. Four pre-operative factors were independently associated with poor prognosis: age?>?70 years (HR?=?2.18; 95% CI 1.27-3.73), initial stage IV (HR?=?2.37; 95% CI 1.18-4.76), disease free interval??70 years, initial stage IV, disease-free interval?

SUBMITTER: Lupato V 

PROVIDER: S-EPMC7804332 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature