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Truncation of 3? CCND1 by t(11;22) leads to negative SP4 CCND1 immunohistochemistry in blastoid mantle cell lymphoma


ABSTRACT: Key Points t(11;22)(q13;q11)/CCND1-IGL resulted in truncation of the CCND1 3? coding sequences in a case of blastoid variant mantle cell lymphoma. The translocation generated CCND1 with a C-terminal alteration, leading to negative CCND1 immunohistochemistry by SP4 monoclonal antibody.

SUBMITTER: Maekawa F 

PROVIDER: S-EPMC7805338 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature

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