Ontology highlight
ABSTRACT:
SUBMITTER: Wu J
PROVIDER: S-EPMC7805459 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Wu Junru J Cyr Anthony A Gruen Danielle S DS Lovelace Tyler C TC Benos Panayiotis V PV Chen Tianmeng T Guyette Francis X FX Yazer Mark H MH Daley Brian J BJ Miller Richard S RS Harbrecht Brian G BG Claridge Jeffrey A JA Phelan Herb A HA Zuckerbraun Brian S BS Neal Matthew D MD Johansson Pär I PI Stensballe Jakob J Namas Rami A RA Vodovotz Yoram Y Sperry Jason L JL Billiar Timothy R TR
Research square 20210108
Alterations in lipid metabolism have the potential to be markers as well as drivers of the pathobiology of acute critical illness. Here, we took advantage of the temporal precision offered by trauma as a common cause of critical illness to identify the dynamic patterns in the circulating lipidome in critically ill humans. The major findings include an early loss of all classes of circulating lipids followed by a delayed and selective lipogenesis in patients destined to remain critically ill. Ear ...[more]