Ontology highlight
ABSTRACT:
SUBMITTER: Yu JS
PROVIDER: S-EPMC7806237 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Science advances 20210113 3
The classic NF-κB pathway plays crucial roles in various immune responses and inflammatory diseases. Its key kinase, IKKβ, participates in a variety of pathological and physiological processes by selectively recognizing its downstream substrates, including p105, p65, and IκBα, but the specific mechanisms of these substrates are unclear. Hyperactivation of one of the substrates, p105, is closely related to the onset of inflammatory bowel disease (IBD) in <i>Nfkb1</i>-deficient mice. In this study ...[more]