Ontology highlight
ABSTRACT:
SUBMITTER: Mykytyn AZ
PROVIDER: S-EPMC7806259 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Mykytyn Anna Z AZ Breugem Tim I TI Riesebosch Samra S Schipper Debby D van den Doel Petra B PB Rottier Robbert J RJ Lamers Mart M MM Haagmans Bart L BL
eLife 20210104
Coronavirus entry is mediated by the spike protein that binds the receptor and mediates fusion after cleavage by host proteases. The proteases that mediate entry differ between cell lines, and it is currently unclear which proteases are relevant in vivo. A remarkable feature of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike is the presence of a multibasic cleavage site (MBCS), which is absent in the SARS-CoV spike. Here, we report that the SARS-CoV-2 spike MBCS increases ...[more]