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Alterations in B cell subsets correlate with body composition parameters in female adolescents with anorexia nervosa.


ABSTRACT: Anorexia nervosa (AN) is a severe eating disorder and often associated with altered humoral immune responses. However, distinct B cell maturation stages in peripheral blood in adolescents with AN have not been characterized. Treatment effects and the relationship between clinical and B cell parameters are also not fully understood. Here we investigated the phenotype of circulating B cell subsets and the relationship with body composition in adolescents with AN before (T0, n?=?24) and after 6 weeks (T1, n?=?20) of treatment. Using multi-parameter flow cytometry, we found increased percentages of antigen-experienced B cells and plasmablasts in patients with AN compared to healthy controls (n?=?20). In contrast, percentages of CD1d+CD5+ B cells and transitional B cells with immunoregulatory roles were reduced at T0 and T1. These B cell frequencies correlated positively with fat mass, fat mass index (FMI), free fat mass index, and body mass index standard deviation score. In addition, scavenger-like receptor CD5 expression levels were downregulated on transitional B cells and correlated with fat mass and FMI in AN. Our findings that regulatory B cell subgroups were reduced in AN and their strong relationship with body composition parameters point toward an impact of immunoregulatory B cells in the pathogenesis of AN.

SUBMITTER: Freff J 

PROVIDER: S-EPMC7806719 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature

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Alterations in B cell subsets correlate with body composition parameters in female adolescents with anorexia nervosa.

Freff Jana J   Schwarte Kathrin K   Bröker Lisa L   Bühlmeier Judith J   Kraft Isabelle I   Öztürk Dana D   Hinney Anke A   Arolt Volker V   Dannlowski Udo U   Romer Georg G   Baune Bernhard T BT   Hebebrand Johannes J   Föcker Manuel M   Alferink Judith J  

Scientific reports 20210113 1


Anorexia nervosa (AN) is a severe eating disorder and often associated with altered humoral immune responses. However, distinct B cell maturation stages in peripheral blood in adolescents with AN have not been characterized. Treatment effects and the relationship between clinical and B cell parameters are also not fully understood. Here we investigated the phenotype of circulating B cell subsets and the relationship with body composition in adolescents with AN before (T0, n = 24) and after 6 wee  ...[more]

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