Unknown

Dataset Information

0

Mitochondrial haplogroup J associated with higher risk of obesity in the Qatari population.


ABSTRACT: Obesity, a major risk factor for metabolic disorders, is highly prevalent in Qatari population. Maternal transmission of obesity traits can be significant; for example, X haplogroup is known to be associated with lower BMI and body fat mass in Northern Europeans and T haplogroup which is a sister haplogroup of J is known to be associated with obesity in Caucasian subjects from Austria and Southern Italy. We aimed to delineate the mitochondrial haplogroups and variants associated with obesity in Qatari population. Mitochondrial genomes of 864 Qatari individuals were extracted from whole exome sequencing data with an average coverage of 77X. We distributed the participants into 2 sub-cohorts: obese (BMI???30) and non-obese (BMI?

SUBMITTER: Dashti M 

PROVIDER: S-EPMC7806807 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature

altmetric image

Publications

Mitochondrial haplogroup J associated with higher risk of obesity in the Qatari population.

Dashti Mohammed M   Alsaleh Hussain H   Rodriguez-Flores Juan L JL   Eaaswarkhanth Muthukrishnan M   Al-Mulla Fahd F   Thanaraj Thangavel Alphonse TA  

Scientific reports 20210113 1


Obesity, a major risk factor for metabolic disorders, is highly prevalent in Qatari population. Maternal transmission of obesity traits can be significant; for example, X haplogroup is known to be associated with lower BMI and body fat mass in Northern Europeans and T haplogroup which is a sister haplogroup of J is known to be associated with obesity in Caucasian subjects from Austria and Southern Italy. We aimed to delineate the mitochondrial haplogroups and variants associated with obesity in  ...[more]

Similar Datasets

| S-EPMC7463505 | biostudies-literature
| S-EPMC3713591 | biostudies-literature
| S-EPMC4556186 | biostudies-literature
| S-EPMC2834599 | biostudies-literature
| S-EPMC4934876 | biostudies-literature
| S-EPMC7645148 | biostudies-literature
| S-EPMC6459174 | biostudies-literature
| S-EPMC8335663 | biostudies-literature
| S-EPMC7831202 | biostudies-literature
| S-EPMC4834861 | biostudies-literature