Identification of ancestry proportions in admixed groups across the Americas using clinical pharmacogenomic SNP panels.
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ABSTRACT:
SUBMITTER: Debortoli G
PROVIDER: S-EPMC7806998 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Publications
Identification of ancestry proportions in admixed groups across the Americas using clinical pharmacogenomic SNP panels.
Debortoli Guilherme G de Araujo Gilderlanio Santana GS Fortes-Lima Cesar C Parra Esteban J EJ Suarez-Kurtz Guilherme G
Scientific reports 20210113 1
We evaluated the performance of three PGx panels to estimate biogeographical ancestry: the DMET panel, and the VIP and Preemptive PGx panels described in the literature. Our analysis indicate that the three panels capture quite well the individual variation in admixture proportions observed in recently admixed populations throughout the Americas, with the Preemptive PGx and DMET panels performing better than the VIP panel. We show that these panels provide reliable information about biogeographi ...[more]
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