Dataset Information

Real-world disease activity and sociodemographic, clinical and treatment characteristics of moderate-to-severe inflammatory bowel disease in Brazil.

ABSTRACT:

Background

Understanding the treatment landscape of inflammatory bowel diseases (IBD) is essential for improving disease management and patient outcomes. Brazil is the largest Latin American country, and it presents socioeconomic and health care differences across its geographical regions. This country has the highest increase in IBD incidence and prevalence in Latin America, but information about the clinical and treatment characteristics of IBD is scarce.

Aim

To describe the sociodemographic, clinical, and treatment characteristics of IBD outpatients in Brazil overall and in the Southeast, South and Northeast/Midwest regions.

Methods

Multicenter, cross-sectional study with a 3-year retrospective chart review component. Patients with moderate-to-severe Crohn's disease (CD) or ulcerative colitis (UC) were consecutively enrolled between October 2016 and February 2017. Active CD at enrollment was defined as a Harvey Bradshaw Index ? 8 or a CD Activity Index ? 220 or a calprotectin level > 200 ?g/g or an active result based on colonoscopy suggestive of inadequate control during the previous year; active UC was defined as a partial Mayo score ? 5. Descriptive statistics were used to analyze all variables.

Results

In a total of 407 included patients, CD was more frequent than UC, both overall (264 CD/143 UC patients) and by region (CD:UC ratios of 2.1 in the Southeast, 1.6 in the South and 1.2 in the Northeast/Midwest). The majority of patients were female (54.2% of CD; 56.6% of UC), and the mean ages were 45.9 ± 13.8 years (CD) and 42.9 ± 13.0 years (UC). The median disease duration was 10.0 (range: 0.5-45) years for both IBD types. At enrollment, 44.7% [95% confidence interval (CI): 38.7-50.7] of CD patients and 25.2% (95%CI: 18.1-32.3) of UC patients presented with active disease. More than 95% of IBD patients were receiving treatment at enrollment; CD patients were commonly treated with biologics (71.6%) and immunosuppressors (67.4%), and UC patients were commonly treated with mesalazine [5-Aminosalicylic acid (5-ASA)] derivates (69.9%) and immunosuppressors (44.1%). More than 50% of the CD patients had ileocolonic disease, and 41.7% presented with stricturing disease. One-quarter of CD patients had undergone CD-related surgery in the past 3 years, and this proportion was lower in the Northeast/Midwest region (2.9%).

Conclusion

In Brazil, there are regional variations in IBD management. CD outweighs UC in both frequency and disease activity. However, one-quarter of UC patients have active disease, and most are receiving 5-ASA treatment.

SUBMITTER: Zaltman C

PROVIDER: S-EPMC7807300 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature

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Publications

Real-world disease activity and sociodemographic, clinical and treatment characteristics of moderate-to-severe inflammatory bowel disease in Brazil.

Zaltman Cyrla C Parra Rogério Serafim RS Sassaki Ligia Yukie LY Santana Genoile Oliveira GO Ferrari Maria de Lourdes Abreu MLA Miszputen Sender J SJ Amarante Heda M B S HMBS Kaiser Junior Roberto Luiz RL Flores Cristina C Catapani Wilson R WR Parente José Miguel Luz JML Bafutto Mauro M Ramos Odery O Gonçalves Carolina D CD Guimaraes Isabella Miranda IM da Rocha Jose J R JJR Feitosa Marley R MR Feres Omar O Saad-Hossne Rogerio R Penna Francisco Guilherme Cancela FGC Cunha Pedro Ferrari Sales PFS Gomes Tarcia Nf TN Nones Rodrigo Bremer RB Faria Mikaell Alexandre Gouvea MAG Parente Mírian Perpétua Palha Dias MPPD Scotton António S AS Caratin Rosana Fusaro RF Senra Juliana J Chebli Júlio Maria JM

World journal of gastroenterology 20210101 2

<h4>Background</h4>Understanding the treatment landscape of inflammatory bowel diseases (IBD) is essential for improving disease management and patient outcomes. Brazil is the largest Latin American country, and it presents socioeconomic and health care differences across its geographical regions. This country has the highest increase in IBD incidence and prevalence in Latin America, but information about the clinical and treatment characteristics of IBD is scarce.<h4>Aim</h4>To describe the soc ...[more]

PMID: 33510560

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Dataset Information

Real-world disease activity and sociodemographic, clinical and treatment characteristics of moderate-to-severe inflammatory bowel disease in Brazil.

Background

Aim

Methods

Results

Conclusion

Publications

Real-world disease activity and sociodemographic, clinical and treatment characteristics of moderate-to-severe inflammatory bowel disease in Brazil.

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