Ontology highlight
ABSTRACT: Background and purpose
Minimizing radiation dose exposure to nearby organs is key to limiting clinical toxicities associated with radiotherapy. Several treatment modalities such as split- or whole-field intensity-modulated radiotherapy (SF-IMRT, WF-IMRT) and volumetric modulated arc therapy (VMAT) are being used to treat tonsillar cancer patients with unilateral neck radiotherapy. Herein, we provide a modern dosimetric comparison of all three techniques.Materials and methods
Forty patients with tonsillar cancer treated with definitive, ipsilateral neck SF-IMRT were evaluated. Each patient was re-planned with WF-IMRT and VMAT techniques, and doses to selected organs-at-risk (OARs) including the larynx, esophagus, and brainstem were compared.Results
No significant differences in target coverage existed between plans; however, the heterogeneity index improved using WF-IMRT and VMAT relative to SF-IMRT. Compared to SF-IMRT, WF-IMRT and VMAT plans had significantly lower mean doses to the supraglottic larynx (31?Gy, 18.5?Gy, 17?Gy; p?ConclusionIn the setting of unilateral neck radiotherapy, WF-IMRT and VMAT plans can be optimized to significantly improve dose sparing of critical structures compared to SF-IMRT. VMAT offers additional advantages of shorter treatment times and fewer required monitor units.
SUBMITTER: Moreno AC
PROVIDER: S-EPMC7807534 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Moreno Amy C AC Wilke Christopher C Wang He H Tung Shi-Ming Samuel SS Pollard Courtney C Garden Adam S AS Morrison William H WH Rosenthal David I DI Fuller Clifton D CD Gunn Gary B GB Reddy Jay P JP Shah Shalin J SJ Frank Steven J SJ Takiar Vinita V Phan Jack J
Physics and imaging in radiation oncology 20190401
<h4>Background and purpose</h4>Minimizing radiation dose exposure to nearby organs is key to limiting clinical toxicities associated with radiotherapy. Several treatment modalities such as split- or whole-field intensity-modulated radiotherapy (SF-IMRT, WF-IMRT) and volumetric modulated arc therapy (VMAT) are being used to treat tonsillar cancer patients with unilateral neck radiotherapy. Herein, we provide a modern dosimetric comparison of all three techniques.<h4>Materials and methods</h4>Fort ...[more]