PH-Dependent peptide bond formation by the selective coupling of ?-amino acids in water.
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ABSTRACT:
SUBMITTER: Wu LF
PROVIDER: S-EPMC7808311 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Publications
pH-Dependent peptide bond formation by the selective coupling of α-amino acids in water.
Wu Long-Fei LF Liu Ziwei Z Sutherland John D JD
Chemical communications (Cambridge, England) 20210101 1
A novel mechanism enabling selective peptide elongation by coupling α-amino acids over other potentially competing prebiotic amines under acidic aqueous condition is suggested. It proceeds via the generation of a carboxylic acid anhydride intermediate with subsequent intramolecular formation of the amide bond. ...[more]
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