Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.
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ABSTRACT:
SUBMITTER: Gordon DE
PROVIDER: S-EPMC7808408 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Publications
Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.
Gordon David E DE Hiatt Joseph J Bouhaddou Mehdi M Rezelj Veronica V VV Ulferts Svenja S Braberg Hannes H Jureka Alexander S AS Obernier Kirsten K Guo Jeffrey Z JZ Batra Jyoti J Kaake Robyn M RM Weckstein Andrew R AR Owens Tristan W TW Gupta Meghna M Pourmal Sergei S Titus Erron W EW Cakir Merve M Soucheray Margaret M McGregor Michael M Cakir Zeynep Z Jang Gwendolyn G O'Meara Matthew J MJ Tummino Tia A TA Zhang Ziyang Z Foussard Helene H Rojc Ajda A Zhou Yuan Y Kuchenov Dmitry D Hüttenhain Ruth R Xu Jiewei J Eckhardt Manon M Swaney Danielle L DL Fabius Jacqueline M JM Ummadi Manisha M Tutuncuoglu Beril B Rathore Ujjwal U Modak Maya M Haas Paige P Haas Kelsey M KM Naing Zun Zar Chi ZZC Pulido Ernst H EH Shi Ying Y Barrio-Hernandez Inigo I Memon Danish D Petsalaki Eirini E Dunham Alistair A Marrero Miguel Correa MC Burke David D Koh Cassandra C Vallet Thomas T Silvas Jesus A JA Azumaya Caleigh M CM Billesbølle Christian C Brilot Axel F AF Campbell Melody G MG Diallo Amy A Dickinson Miles Sasha MS Diwanji Devan D Herrera Nadia N Hoppe Nick N Kratochvil Huong T HT Liu Yanxin Y Merz Gregory E GE Moritz Michelle M Nguyen Henry C HC Nowotny Carlos C Puchades Cristina C Rizo Alexandrea N AN Schulze-Gahmen Ursula U Smith Amber M AM Sun Ming M Young Iris D ID Zhao Jianhua J Asarnow Daniel D Biel Justin J Bowen Alisa A Braxton Julian R JR Chen Jen J Chio Cynthia M CM Chio Un Seng US Deshpande Ishan I Doan Loan L Faust Bryan B Flores Sebastian S Jin Mingliang M Kim Kate K Lam Victor L VL Li Fei F Li Junrui J Li Yen-Li YL Li Yang Y Liu Xi X Lo Megan M Lopez Kyle E KE Melo Arthur A AA Moss Frank R FR Nguyen Phuong P Paulino Joana J Pawar Komal Ishwar KI Peters Jessica K JK Pospiech Thomas H TH Safari Maliheh M Sangwan Smriti S Schaefer Kaitlin K Thomas Paul V PV Thwin Aye C AC Trenker Raphael R Tse Eric E Tsui Tsz Kin Martin TKM Wang Feng F Whitis Natalie N Yu Zanlin Z Zhang Kaihua K Zhang Yang Y Zhou Fengbo F Saltzberg Daniel D Hodder Anthony J AJ Shun-Shion Amber S AS Williams Daniel M DM White Kris M KM Rosales Romel R Kehrer Thomas T Miorin Lisa L Moreno Elena E Patel Arvind H AH Rihn Suzannah S Khalid Mir M MM Vallejo-Gracia Albert A Fozouni Parinaz P Simoneau Camille R CR Roth Theodore L TL Wu David D Karim Mohd Anisul MA Ghoussaini Maya M Dunham Ian I Berardi Francesco F Weigang Sebastian S Chazal Maxime M Park Jisoo J Logue James J McGrath Marisa M Weston Stuart S Haupt Robert R Hastie C James CJ Elliott Matthew M Brown Fiona F Burness Kerry A KA Reid Elaine E Dorward Mark M Johnson Clare C Wilkinson Stuart G SG Geyer Anna A Giesel Daniel M DM Baillie Carla C Raggett Samantha S Leech Hannah H Toth Rachel R Goodman Nicola N Keough Kathleen C KC Lind Abigail L AL Klesh Reyna J RJ Hemphill Kafi R KR Carlson-Stevermer Jared J Oki Jennifer J Holden Kevin K Maures Travis T Pollard Katherine S KS Sali Andrej A Agard David A DA Cheng Yifan Y Fraser James S JS Frost Adam A Jura Natalia N Kortemme Tanja T Manglik Aashish A Southworth Daniel R DR Stroud Robert M RM Alessi Dario R DR Davies Paul P Frieman Matthew B MB Ideker Trey T Abate Carmen C Jouvenet Nolwenn N Kochs Georg G Shoichet Brian B Ott Melanie M Palmarini Massimo M Shokat Kevan M KM García-Sastre Adolfo A Rassen Jeremy A JA Grosse Robert R Rosenberg Oren S OS Verba Kliment A KA Basler Christopher F CF Vignuzzi Marco M Peden Andrew A AA Beltrao Pedro P Krogan Nevan J NJ
Science (New York, N.Y.) 20201015 6521
The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a grave threat to public health and the global economy. SARS-CoV-2 is closely related to the more lethal but less transmissible coronaviruses SARS-CoV-1 and Middle East respiratory syndrome coronavirus (MERS-CoV). Here, we have carried out comparative viral-human protein-protein interaction and viral protein localization analyses for all three viruses. Subsequent functional genetic screening identif ...[more]
