Dataset Information

Facilitating the natural semi-drying of oily sludge by changing the form of water.

ABSTRACT: Reducing the water content of oily sludge is essential for the disposal of it. Despite conditioning and solid-liquid separation, the water content of oily sludge generally exceeds 65%. A large amount of this water exists in the form of emulsified and bound water, reducing the efficiency of water removal during the natural semi-drying process of oily sludge. To shorten the time required for natural semi-drying, this study applied an orthogonal test to screen an oily sludge modified material (OSM). The effect and mechanism of OSM on the natural semi-drying of oily sludge were studied using a thermal gravimetric analyzer (TGA), scanning electron microscope (SEM), surface tension measurement, and microscopic observations. The results show that when the ambient temperature exceeded 10°C, the OSM increased in mass by 8-10%, and the time required for the natural semi-drying of oily sludge was shortened from 15 days to less than 5 days. OSM can rupture the emulsion, reduce the surface tension, convert the emulsion and bound water in the oily sludge into free water, and accelerate the rate of water migration, diffusion, and natural evaporation from the inside of the oily sludge to the surface and air. The research results show that changing the form of water can speed up the drying of oily sludge, creating positive economic benefits in the process of oily sludge reduction and recycling.

SUBMITTER: Liu Y

PROVIDER: S-EPMC7808663 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature

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Facilitating the natural semi-drying of oily sludge by changing the form of water.

Liu Yucheng Y Wang Maoren M Chen Mingyan M Zhu Meng M Liao Maoqi M

PloS one 20210114 1

Reducing the water content of oily sludge is essential for the disposal of it. Despite conditioning and solid-liquid separation, the water content of oily sludge generally exceeds 65%. A large amount of this water exists in the form of emulsified and bound water, reducing the efficiency of water removal during the natural semi-drying process of oily sludge. To shorten the time required for natural semi-drying, this study applied an orthogonal test to screen an oily sludge modified material (OSM) ...[more]

PMID: 33444389

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Project description:BACKGROUND:OZ439 is a new chemical entity which is active against drug-resistant malaria and shows potential as a single-dose cure. However, development of an oral formulation with desired exposure has proved problematic, as OZ439 is poorly soluble (BCS Class II drug). In order to be feasible for low and middle income countries (LMICs), any process to create or formulate such a therapeutic must be inexpensive at scale, and the resulting formulation must survive without refrigeration even in hot, humid climates. We here demonstrate the scalability and stability of a nanoparticle (NP) formulation of OZ439. Previously, we applied a combination of hydrophobic ion pairing and Flash NanoPrecipitation (FNP) to formulate OZ439 NPs 150 nm in diameter using the inexpensive stabilizer hydroxypropyl methylcellulose acetate succinate (HPMCAS). Lyophilization was used to process the NPs into a dry form, and the powder's in vitro solubilization was over tenfold higher than unprocessed OZ439. METHODS:In this study, we optimize our previous formulation using a large-scale multi-inlet vortex mixer (MIVM). Spray drying is a more scalable and less expensive operation than lyophilization and is, therefore, optimized to produce dry powders. The spray dried powders are then subjected to a series of accelerated aging stability trials at high temperature and humidity conditions. RESULTS:The spray dried OZ439 powder's dissolution kinetics are superior to those of lyophilized NPs. The powder's OZ439 solubilization profile remains constant after 1 month in uncapped vials in an oven at 50 °C and 75% RH, and for 6 months in capped vials at 40 °C and 75% RH. In fasted-state intestinal fluid, spray dried NPs achieved 80-85% OZ439 dissolution, to a concentration of 430 µg/mL, within 3 h. In fed-state intestinal fluid, 95-100% OZ439 dissolution is achieved within 1 h, to a concentration of 535 µg/mL. X-ray powder diffraction and differential scanning calorimetry profiles similarly remain constant over these periods. CONCLUSIONS:The combined nanofabrication and drying process described herein, which utilizes two continuous unit operations that can be operated at scale, is an important step toward an industrially-relevant method of formulating the antimalarial OZ439 into a single-dose oral form with good stability against humidity and temperature.

Project description:A new sanitation technology has been proposed in which a laminated hydrophobic membrane contains and enhances drying of fecal sludge in a toilet, with particular focus on application to urban regions of low-income countries. The proposed technology uses a laminated hydrophobic membrane liner as an integral component of container-based sanitation systems. The focus of this study is to quantitatively evaluate the laminate's clogging after repeated use, which will affect replacement interval and might limit the laminate's application in container-based toilets. The membrane of the laminated hydrophobic membrane used in this process is hydrophobic and only allows vapor transport. Drying of water vapor using the laminated hydrophobic membrane occurs due to moderate temperature or humidity gradients, while other constituents such as aqueous dissolved solutes of fecal sludge are retained. Controlled laboratory experiments evaluated repeated use of a laminated hydrophobic membrane for fecal sludge drying, with mild brushing/rinsing of the laminate between each application. Drying occurred at a constant rate as long as the fecal sludge moisture content exceeded 11.6 (g/g), below which water activity <1. Over five drying cycles, at a significance level of ??=?0.05 the dimensionless drying rate in the constant-rate period was not reduced. While scanning electron microscopy and energy dispersive X-ray analyses of used laminated hydrophobic membrane showed deposition of fecal sludge on the inner fabric of the laminate, particulate accumulation was never sufficient to alter the fecal sludge drying rate. Experiments with only water indicated that the fecal sludge increased the effective diffusion length through the laminate by 10-30%. These data demonstrate that clogging of the laminated hydrophobic membrane is minor over five cycles of fecal sludge drying with mild rinsing between cycles, indicating that use of the laminate may be feasible in many field applications.

Dataset Information

Facilitating the natural semi-drying of oily sludge by changing the form of water.

Publications

Facilitating the natural semi-drying of oily sludge by changing the form of water.

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