Ontology highlight
ABSTRACT:
SUBMITTER: Cover CG
PROVIDER: S-EPMC7809041 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Cover Christopher G CG Kesner Andrew J AJ Ukani Shehzad S Stein Elliot A EA Ikemoto Satoshi S Yang Yihong Y Lu Hanbing H
Communications biology 20210114 1
Intracranial self-stimulation, in which an animal performs an operant response to receive regional brain electrical stimulation, is a widely used procedure to study motivated behavior. While local neuronal activity has long been measured immediately before or after the operant, imaging the whole brain in real-time remains a challenge. Herein we report a method that permits functional MRI (fMRI) of brain dynamics while mice are cued to perform an operant task: licking a spout to receive optogenet ...[more]