Ontology highlight
ABSTRACT:
SUBMITTER: Bayele HK
PROVIDER: S-EPMC7809393 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
Bayele Henry K HK Srai Surjit Kaila S SKS
Biochemistry and biophysics reports 20210108
Ferroportin (Fpn/IREG1/MTP1) is the only known transporter mediating iron efflux from epithelial cells and macrophages, and thus regulates how much iron is released into the circulation. Consequently, Fpn mutations are associated with haemochromatosis. Fpn itself is post-translationally regulated by hepcidin (Hepc) which induces its redistribution and degradation in a ubiquitin-dependent process. Together, the two proteins appear to be the nexus for iron homeostasis. Here we show that a rare gai ...[more]