Ontology highlight
ABSTRACT:
SUBMITTER: de Aguiar RB
PROVIDER: S-EPMC7809466 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
de Aguiar Rodrigo Barbosa RB da Silva Tábata de Almeida TA Costa Bruno Andrade BA Machado Marcelo Ferreira Marcondes MFM Yamada Renata Yoshiko RY Braggion Camila C Perez Kátia Regina KR Mori Marcelo Alves Silva MAS Oliveira Vitor V de Moraes Jane Zveiter JZ
Scientific reports 20210114 1
Single-chain variable fragments (scFvs) are small-sized artificial constructs composed of the immunoglobulin heavy and light chain variable regions connected by a peptide linker. We have previously described an anti-fibroblast growth factor 2 (FGF2) immunoglobulin G (IgG) monoclonal antibody (mAb), named 3F12E7, with notable antitumor potential revealed by preclinical assays. FGF2 is a known angiogenesis-associated molecule implicated in tumor progression. In this report, we describe a recombina ...[more]