Prioritizing transcriptional factors in gene regulatory networks with PageRank.

ABSTRACT: Biological states are controlled by orchestrated transcriptional factors (TFs) within gene regulatory networks. Here we show TFs responsible for the dynamic changes of biological states can be prioritized with temporal PageRank. We further show such TF prioritization can be extended by integrating gene regulatory networks reverse engineered from multi-omics profiles, e.g. gene expression, chromatin accessibility, and chromosome conformation assays, using multiplex PageRank.

SUBMITTER: Ding H 

PROVIDER: S-EPMC7809505 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature