Ontology highlight
ABSTRACT:
SUBMITTER: Bayoumi M
PROVIDER: S-EPMC7809690 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Nano letters 20201219 1
We present a synthetic nanoscale piston that uses chemical energy to perform molecular transport against an applied bias. Such a device comprises a 13 by 5 nm protein cylinder, embedded in a biological membrane enclosing a single-stranded DNA (ssDNA) rod. Hybridization with DNA cargo rigidifies the rod, allowing for transport of a selected DNA molecule across the nanopore. A strand displacement reaction from ssDNA fuel on the other side of the membrane then liberates the DNA cargo back into solu ...[more]