Membrane protein biogenesis by the EMC.
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ABSTRACT:
SUBMITTER: Alvira S
PROVIDER: S-EPMC7809699 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Publications
Membrane protein biogenesis by the EMC.
Alvira Sara S Corey Robin A RA Collinson Ian I Römisch Karin K
The EMBO journal 20201221 2
The endoplasmic reticulum (ER) membrane protein complex (EMC) was identified over a decade ago in a genetic screen for ER protein homeostasis. The EMC inserts transmembrane domains (TMDs) with limited hydrophobicity. Two recent cryo-EM structures, and a third model based on partial high- and low-resolution structures, suggest how this is accomplished. ...[more]
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