Dataset Information

Exploring the Effects of Cigarette Smoking on Inflammatory Bowel Disease Using Mendelian Randomization.

ABSTRACT:

Background

Previous observational evidence has suggested an association between smoking and inflammatory bowel disease (IBD).

Methods

We used observational techniques followed by Mendelian randomization to explore whether smoking is a causal factor in the development of IBD and its subtypes.

Results

In those who have ever smoked, we observed increased risk of IBD and, in current smokers, we observed increased risk of Crohn disease and decreased risk of ulcerative colitis. However, our Mendelian randomization analyses found little evidence that smoking affects the development of IBD.

Conclusion

Overall, our results suggest that smoking does not causally influence the risk of IBD.

SUBMITTER: Jones DP

PROVIDER: S-EPMC7809707 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature

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Publications

Exploring the Effects of Cigarette Smoking on Inflammatory Bowel Disease Using Mendelian Randomization.

Jones Daniel P DP Richardson Tom G TG Davey Smith George G Gunnell David D Munafò Marcus R MR Wootton Robyn E RE

Crohn's & colitis 360 20200101 1

<h4>Background</h4>Previous observational evidence has suggested an association between smoking and inflammatory bowel disease (IBD).<h4>Methods</h4>We used observational techniques followed by Mendelian randomization to explore whether smoking is a causal factor in the development of IBD and its subtypes.<h4>Results</h4>In those who have ever smoked, we observed increased risk of IBD and, in current smokers, we observed increased risk of Crohn disease and decreased risk of ulcerative colitis. H ...[more]

PMID: 33506196

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Project description:BackgroundThe causal genetic relationship between common parenteral manifestations of inflammatory bowel disease (IBD) and urolithiasis remains unclear because their timing is difficult to determine. This study investigated the causal genetic association between IBD and urolithiasis using Mendelian randomization (MR) based on data from large population-based genome-wide association studies (GWASs).MethodsA two-sample MR analysis was performed to assess the potential relationship between IBD and urolithiasis. Specific single nucleotide polymorphism data were obtained from GWASs, including IBD (n = 59957) and its main subtypes, Crohn's disease (CD) (n = 40266) and ulcerative colitis (UC) (n = 45975). Summarized data on urolithiasis (n = 218792) were obtained from different GWAS studies. A random-effects model was analyzed using inverse-variance weighting, MR-Egger, and weighted medians.ResultsGenetic predisposition to IBD and the risk of urolithiasis were significantly associated [odds ratio (OR), 1.04 (95% confidence interval [CI], 1.00-.08), P = 0.01]. Consistently, the weighted median method yielded similar results [OR, 1.06 (95% CI, 1.00-1.12), P = 0.02]. The MR-Egger method also demonstrated comparable findings [OR, 1.02 (95% CI, 0.96-1.08), P = 0.45]. Both funnel plots and MR-Egger intercepts indicated no directional pleiotropic effects between IBD and urolithiasis. CD was strongly associated with it in its subtype analysis [OR, 1.04 (95% CI, 1.01-1.07), P = 0.01], and UC was also causally associated with urolithiasis, although the association was not significant [OR, 0.99 (95% CI, 0.95-1.03), P = 0.71].ConclusionA unidirectional positive causal correlation was identified between IBD and urolithiasis, with varying degrees of association observed among the different subtypes of IBD. Recognizing the increased incidence of urolithiasis in patients with IBD is crucial in clinical practice. Early detection and surveillance of IBD, improved patient awareness, adoption of preventive strategies, and promotion of collaborative efforts among healthcare providers regarding treatment methodologies are vital for improving patient outcomes.

Dataset Information

Exploring the Effects of Cigarette Smoking on Inflammatory Bowel Disease Using Mendelian Randomization.

Background

Methods

Results

Conclusion

Publications

Exploring the Effects of Cigarette Smoking on Inflammatory Bowel Disease Using Mendelian Randomization.

Similar Datasets

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