Ontology highlight
ABSTRACT:
SUBMITTER: Draffin JE
PROVIDER: S-EPMC7809792 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Draffin Jonathan E JE Sánchez-Castillo Carla C Fernández-Rodrigo Alba A Sánchez-Sáez Xavier X Ávila Jesús J Wagner Florence F FF Esteban José A JA
The EMBO journal 20201116 2
Glycogen synthase kinase-3 (GSK3) is an important signalling protein in the brain and modulates different forms of synaptic plasticity. Neuronal functions of GSK3 are typically attributed to one of its two isoforms, GSK3β, simply because of its prevalent expression in the brain. Consequently, the importance of isoform-specific functions of GSK3 in synaptic plasticity has not been fully explored. We now directly address this question for NMDA receptor-dependent long-term depression (LTD) in the h ...[more]