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In situ measurements of intracellular thermal conductivity using heater-thermometer hybrid diamond nanosensors.


ABSTRACT: Understanding heat dissipation processes at nanoscale during cellular thermogenesis is essential to clarify the relationships between the heat and biological processes in cells and organisms. A key parameter determining the heat flux inside a cell is the local thermal conductivity, a factor poorly investigated both experimentally and theoretically. Here, using a nanoheater/nanothermometer hybrid made of a polydopamine encapsulating a fluorescent nanodiamond, we measured the intracellular thermal conductivities of HeLa and MCF-7 cells with a spatial resolution of about 200 nm. The mean values determined in these two cell lines are both 0.11 ± 0.04 W m-1 K-1, which is significantly smaller than that of water. Bayesian analysis of the data suggests there is a variation of the thermal conductivity within a cell. These results make the biological impact of transient temperature spikes in a cell much more feasible, and suggest that cells may use heat flux for short-distance thermal signaling.

SUBMITTER: Sotoma S 

PROVIDER: S-EPMC7810374 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature

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In situ measurements of intracellular thermal conductivity using heater-thermometer hybrid diamond nanosensors.

Sotoma Shingo S   Zhong Chongxia C   Kah James Chen Yong JCY   Yamashita Hayato H   Plakhotnik Taras T   Harada Yoshie Y   Suzuki Madoka M  

Science advances 20210115 3


Understanding heat dissipation processes at nanoscale during cellular thermogenesis is essential to clarify the relationships between the heat and biological processes in cells and organisms. A key parameter determining the heat flux inside a cell is the local thermal conductivity, a factor poorly investigated both experimentally and theoretically. Here, using a nanoheater/nanothermometer hybrid made of a polydopamine encapsulating a fluorescent nanodiamond, we measured the intracellular thermal  ...[more]

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