Ontology highlight
ABSTRACT:
SUBMITTER: Montigny C
PROVIDER: S-EPMC7810697 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Montigny Cédric C Huang Dong Liang DL Beswick Veronica V Barbot Thomas T Jaxel Christine C le Maire Marc M Zheng Ji-Shen JS Jamin Nadège N
Scientific reports 20210115 1
Sarcolipin (SLN), a single-spanning membrane protein, is a regulator of the sarco-endoplasmic reticulum Ca<sup>2+</sup>-ATPase (SERCA1a). Chemically synthesized SLN, palmitoylated or not (pSLN or SLN), and recombinant wild-type rabbit SERCA1a expressed in S. cerevisiae design experimental conditions that provide a deeper understanding of the functional role of SLN on the regulation of SERCA1a. Our data show that chemically synthesized SLN interacts with recombinant SERCA1a, with calcium-deprived ...[more]