CD79a promotes CNS-infiltration and leukemia engraftment in pediatric B-cell precursor acute lymphoblastic leukemia.
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ABSTRACT:
SUBMITTER: Lenk L
PROVIDER: S-EPMC7810877 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Publications
CD79a promotes CNS-infiltration and leukemia engraftment in pediatric B-cell precursor acute lymphoblastic leukemia.
Lenk Lennart L Carlet Michela M Vogiatzi Fotini F Spory Lea L Winterberg Dorothee D Cousins Antony A Vossen-Gajcy Michaela M Ibruli Olta O Vokuhl Christian C Cario Gunnar G El Ayoubi Omar O Kramer Lisa L Ritgen Matthias M Brüggemann Monika M Häsler Robert R Schrappe Martin M Fuhrmann Stephan S Halsey Christina C Jeremias Irmela I Hobeika Elias E Jumaa Hassan H Alsadeq Ameera A Schewe Denis M DM
Communications biology 20210115 1
Central nervous system (CNS) involvement remains a challenge in the diagnosis and treatment of acute lymphoblastic leukemia (ALL). In this study, we identify CD79a (also known as Igα), a signaling component of the preB cell receptor (preBCR), to be associated with CNS-infiltration and -relapse in B-cell precursor (BCP)-ALL patients. Furthermore, we show that downregulation of CD79a hampers the engraftment of leukemia cells in different murine xenograft models, particularly in the CNS. ...[more]
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