Ontology highlight
ABSTRACT:
SUBMITTER: Hu X
PROVIDER: S-EPMC7811004 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Hu Xiaoding X Villodre Emilly S ES Larson Richard R Rahal Omar M OM Wang Xiaoping X Gong Yun Y Song Juhee J Krishnamurthy Savitri S Ueno Naoto T NT Tripathy Debu D Woodward Wendy A WA Debeb Bisrat G BG
Communications biology 20210115 1
Inflammatory breast cancer (IBC) is a clinically distinct and highly aggressive form of breast cancer with rapid onset and a strong propensity to metastasize. The molecular mechanisms underlying the aggressiveness and metastatic propensity of IBC are largely unknown. Herein, we report that decorin (DCN), a small leucine-rich extracellular matrix proteoglycan, is downregulated in tumors from patients with IBC. Overexpression of DCN in IBC cells markedly decreased migration, invasion, and cancer s ...[more]