Ontology highlight
ABSTRACT:
SUBMITTER: Di Carluccio C
PROVIDER: S-EPMC7811138 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Di Carluccio Cristina C Forgione Rosa Ester RE Montefiori Marco M Civera Monica M Sattin Sara S Smaldone Giovanni G Fukase K K Manabe Y Y Crocker Paul R PR Molinaro Antonio A Marchetti Roberta R Silipo Alba A
iScience 20201229 1
Siglecs (sialic acid binding immunoglobulin (Ig)-like lectins) constitute a group of 15 human and 9 murine cell-surface transmembrane receptors belonging to the I-type lectin family, mostly expressed on innate immune cells and characterized by broadly similar structural features. Here, the prominent inhibitory CD22 (Siglec-2), well known in maintaining tolerance and preventing autoimmune responses on B cells, is studied in its human and murine forms in complex with sialoglycans. In detail, the r ...[more]