Ontology highlight
ABSTRACT:
SUBMITTER: Singh S
PROVIDER: S-EPMC7811140 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
iScience 20201228 1
Histone lysine demethylases (KDMs) play critical roles in oncogenesis and therefore may be effective targets for anticancer therapy. Using a time-resolved fluorescence resonance energy transfer demethylation screen assay, in combination with multiple orthogonal validation approaches, we identified geldanamycin and its analog 17-DMAG as KDM inhibitors. In addition, we found that these Hsp90 inhibitors increase degradation of the alveolar rhabdomyosarcoma (aRMS) driver oncoprotein PAX3-FOXO1 and i ...[more]