Ontology highlight
ABSTRACT:
SUBMITTER: Mora M
PROVIDER: S-EPMC7811141 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Mora Marcelo M Mell Joshua Chang JC Ehrlich Garth D GD Ehrlich Rachel L RL Redfield Rosemary J RJ
iScience 20201230 1
The genomes of naturally competent Pasteurellaceae and Neisseriaceae have many short uptake sequences (USS), which allow them to distinguish self-DNA from foreign DNA. To fully characterize this preference we developed genome-wide maps of DNA uptake using both a sequence-based computational model and genomic DNA that had been sequenced after uptake by and recovery from competent <i>Haemophilus influenzae</i> cells. When DNA fragments were shorter than the average USS spacing of ∼1,000 bp, sharp ...[more]