Ontology highlight
ABSTRACT:
SUBMITTER: Kathania M
PROVIDER: S-EPMC7811274 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Kathania Mahesh M Tsakem Elviche L EL Theiss Arianne L AL Venuprasad K K
Journal of immunology (Baltimore, Md. : 1950) 20200313 8
Inflammatory bowel diseases are associated with complex shifts in microbiota composition. However, it remains unclear whether specific subsets of commensal bacteria induce inflammatory bowel diseases in genetically susceptible hosts. In this study, we found that deficiency of the E3 ligase Itch, which leads to spontaneous colitis and rectal prolapse, is associated with alteration of the gut microbiota. 16S rRNA sequencing showed expansion of colitogenic <i>Bacteroides</i> sp. in Itch<sup>-/-</su ...[more]