Effect of interactions between APOE and ESR1 polymorphisms on cognitive functions in postmenopausal women.

ABSTRACT:

Introduction

During menopause the level of estrogens is decreased, which may lead to cognitive impairment or dementia. Some forms of genetic polymorphism were found to be related to cognitive functions, including APOE and ESR1 (PvuII and XbaI) polymorphisms. In the present study we aimed to analyze the impact of interactions between APOE and ESR1 polymorphisms on cognitive functions in the group of postmenopausal women.

Material and methods

The study group consisted of 266 postmenopausal women aged 50-65 years without symptoms of dementia. A computerized battery of the Central Nervous System Vital Signs (CNS VS) test was used to diagnose cognitive functions. APOE and ESR1 polymorphisms were genotyped using multiplex PCR

SUBMITTER: Pinkas J 

PROVIDER: S-EPMC7811303 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature