PCSK9 genetic variants and cognitive abilities: a large-scale Mendelian randomization study.
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ABSTRACT: Introduction
PCSK9 inhibitors lower low-density lipoprotein (LDL) cholesterol and are efficacious at reducing vascular disease, however questions remain about potential effects on cognitive function.Methods
We examined the association of genetic variants in PCSK9 with continuous measures of cognitive ability in UK Biobank. Six independent polymorphisms in PCSK9 were used in up to 337,348 individuals.Results
The PCSK9 allele score was associated with a lower risk of CHD, and weakly with worse log reaction time.Conclusions
We are unable to rule out meaningful associations of PCSK9 genetic variants with cognition, emphasising the potential need for continued pharmacovigilance for patients currently treated with PCSK9 inhibitors.
SUBMITTER: Lyall DM
PROVIDER: S-EPMC7811317 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Publications
<i>PCSK9</i> genetic variants and cognitive abilities: a large-scale Mendelian randomization study.
Lyall Donald M DM Ward Joey J Banach Maciej M Smith George Davey GD Gill Jason G JG Pell Jill P JP Holmes Michael V MV Sattar Naveed N
Archives of medical science : AMS 20210105 1
<h4>Introduction</h4>PCSK9 inhibitors lower low-density lipoprotein (LDL) cholesterol and are efficacious at reducing vascular disease, however questions remain about potential effects on cognitive function.<h4>Methods</h4>We examined the association of genetic variants in <i>PCSK9</i> with continuous measures of cognitive ability in UK Biobank. Six independent polymorphisms in <i>PCSK9</i> were used in up to 337,348 individuals.<h4>Results</h4>The <i>PCSK9</i> allele score was associated with a ...[more]
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