Age-related changes in PD-1 expression coincide with increased cytotoxic potential in Vδ2 T cells during infancy.
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ABSTRACT:
SUBMITTER: Hsu H
PROVIDER: S-EPMC7811364 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Publications
Age-related changes in PD-1 expression coincide with increased cytotoxic potential in Vδ2 T cells during infancy.
Hsu Haoting H Boudova Sarah S Mvula Godfrey G Divala Titus H TH Rach David D Mungwira Randy G RG Boldrin Francesca F Degiacomi Giulia G Manganelli Riccardo R Laufer Miriam K MK Cairo Cristiana C
Cellular immunology 20201113
Human Vγ9Vδ2 T cells respond to several diverse pathogens by sensing microbial cholesterol intermediates. Unlike CD4 T cells, they are poised for rapid Th1-like responses even before birth, which allows them to play a key role in the first line of defense against pathogens in early life. However, their regulation and functional maturation during infancy (in particular the acquisition of cytotoxic potential) remain understudied. We thus characterized their responses to cholesterol intermediates a ...[more]
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