Ontology highlight
ABSTRACT:
SUBMITTER: Momin N
PROVIDER: S-EPMC7811803 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Momin Noor N Mehta Naveen K NK Bennett Nitasha R NR Ma Leyuan L Palmeri Joseph R JR Chinn Magnolia M MM Lutz Emi A EA Kang Byong B Irvine Darrell J DJ Spranger Stefani S Wittrup K Dane KD
Science translational medicine 20190601 498
The clinical application of cytokine therapies for cancer treatment remains limited due to severe adverse reactions and insufficient therapeutic effects. Although cytokine localization by intratumoral administration could address both issues, the rapid escape of soluble cytokines from the tumor invariably subverts this effort. We find that intratumoral administration of a cytokine fused to the collagen-binding protein lumican prolongs local retention and markedly reduces systemic exposure. Combi ...[more]