Ontology highlight
ABSTRACT:
SUBMITTER: Li Z
PROVIDER: S-EPMC7811838 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Li Zhongchi Z Xu Kang K Zhao Sen S Guo Yannan Y Chen Huiling H Ni Jianquan J Liu Qingfei Q Wang Zhao Z
Aging cell 20201213 1
Spermatogenesis-associated protein 4 (SPATA4) is conserved across multiple species. However, the function of this gene remains largely unknown. In this study, we generated Spata4 transgenic mice to explore tissue-specific function of SPATA4. Spata4 overexpression mice displayed increased subcutaneous fat tissue compared with wild-type littermates at an old age, while this difference was not observed in younger mice. Aging-induced ectopic fat distribution, inflammation, and insulin resistance wer ...[more]