Interleukin-6 neutralization ameliorates symptoms in prematurely aged mice.
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ABSTRACT:
SUBMITTER: Squarzoni S
PROVIDER: S-EPMC7811841 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Publications
Interleukin-6 neutralization ameliorates symptoms in prematurely aged mice.
Squarzoni Stefano S Schena Elisa E Sabatelli Patrizia P Mattioli Elisabetta E Capanni Cristina C Cenni Vittoria V D'Apice Maria Rosaria MR Andrenacci Davide D Sarli Giuseppe G Pellegrino Valeria V Festa Anna A Baruffaldi Fabio F Storci Gianluca G Bonafè Massimiliano M Barboni Catia C Sanapo Mara M Zaghini Anna A Lattanzi Giovanna G
Aging cell 20210103 1
Hutchinson-Gilford progeria syndrome (HGPS) causes premature aging in children, with adipose tissue, skin and bone deterioration, and cardiovascular impairment. In HGPS cells and mouse models, high levels of interleukin-6, an inflammatory cytokine linked to aging processes, have been detected. Here, we show that inhibition of interleukin-6 activity by tocilizumab, a neutralizing antibody raised against interleukin-6 receptors, counteracts progeroid features in both HGPS fibroblasts and Lmna<sup> ...[more]
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