Unknown

Dataset Information

0

Review on Databases and Bioinformatic Approaches on Pharmacogenomics of Adverse Drug Reactions.


ABSTRACT: Pharmacogenomics has been used effectively in studying adverse drug reactions by determining the person-specific genetic factors associated with individual response to a drug. Current approaches have revealed the significant importance of sequencing technologies and sequence analysis strategies for interpreting the contribution of genetic variation in developing adverse reactions. Advance in next generation sequencing and platform brings new opportunities in validating the genetic candidates in certain reactions, and could be used to develop the preemptive tests to predict the outcome of the variation in a personal response to a drug. With the highly accumulated available data recently, the in silico approach with data analysis and modeling plays as other important alternatives which significantly support the final decisions in the transformation from research to clinical applications such as diagnosis and treatments for various types of adverse responses.

SUBMITTER: Tong H 

PROVIDER: S-EPMC7812041 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature

altmetric image

Publications

Review on Databases and Bioinformatic Approaches on Pharmacogenomics of Adverse Drug Reactions.

Tong Hang H   Phan Nga V T NVT   Nguyen Thanh T TT   Nguyen Dinh V DV   Vo Nam S NS   Le Ly L  

Pharmacogenomics and personalized medicine 20210113


Pharmacogenomics has been used effectively in studying adverse drug reactions by determining the person-specific genetic factors associated with individual response to a drug. Current approaches have revealed the significant importance of sequencing technologies and sequence analysis strategies for interpreting the contribution of genetic variation in developing adverse reactions. Advance in next generation sequencing and platform brings new opportunities in validating the genetic candidates in  ...[more]

Similar Datasets

| S-EPMC3707028 | biostudies-literature
| S-EPMC3997041 | biostudies-literature
| S-EPMC5555876 | biostudies-literature
| S-EPMC8704264 | biostudies-literature
| S-EPMC6919994 | biostudies-literature
| S-EPMC6311930 | biostudies-literature
| S-EPMC3293884 | biostudies-literature
| S-EPMC8605942 | biostudies-literature
| S-EPMC8624083 | biostudies-literature
| S-EPMC7253354 | biostudies-literature