Ontology highlight
ABSTRACT:
SUBMITTER: Caston RA
PROVIDER: S-EPMC7812272 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Caston Rachel A RA Shah Fenil F Starcher Colton L CL Wireman Randall R Babb Olivia O Grimard Michelle M McGeown Jack J Armstrong Lee L Tong Yan Y Pili Roberto R Rupert Joseph J Zimmers Teresa A TA Elmi Adily N AN Pollok Karen E KE Motea Edward A EA Kelley Mark R MR Fishel Melissa L ML
Journal of cellular and molecular medicine 20201203 2
With a plethora of molecularly targeted agents under investigation in cancer, a clear need exists to understand which pathways can be targeted simultaneously with multiple agents to elicit a maximal killing effect on the tumour. Combination therapy provides the most promise in difficult to treat cancers such as pancreatic. Ref-1 is a multifunctional protein with a role in redox signalling that activates transcription factors such as NF-κB, AP-1, HIF-1α and STAT3. Formerly, we have demonstrated t ...[more]