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The clinical impact of glycobiology: targeting selectins, Siglecs and mammalian glycans.


ABSTRACT: Carbohydrates - namely glycans - decorate every cell in the human body and most secreted proteins. Advances in genomics, glycoproteomics and tools from chemical biology have made glycobiology more tractable and understandable. Dysregulated glycosylation plays a major role in disease processes from immune evasion to cognition, sparking research that aims to target glycans for therapeutic benefit. The field is now poised for a boom in drug development. As a harbinger of this activity, glycobiology has already produced several drugs that have improved human health or are currently being translated to the clinic. Focusing on three areas - selectins, Siglecs and glycan-targeted antibodies - this Review aims to tell the stories behind therapies inspired by glycans and to outline how the lessons learned from these approaches are paving the way for future glycobiology-focused therapeutics.

SUBMITTER: Smith BAH 

PROVIDER: S-EPMC7812346 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature

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The clinical impact of glycobiology: targeting selectins, Siglecs and mammalian glycans.

Smith Benjamin A H BAH   Bertozzi Carolyn R CR  

Nature reviews. Drug discovery 20210118 3


Carbohydrates - namely glycans - decorate every cell in the human body and most secreted proteins. Advances in genomics, glycoproteomics and tools from chemical biology have made glycobiology more tractable and understandable. Dysregulated glycosylation plays a major role in disease processes from immune evasion to cognition, sparking research that aims to target glycans for therapeutic benefit. The field is now poised for a boom in drug development. As a harbinger of this activity, glycobiology  ...[more]

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