Dataset Information

Assessment of health-related quality of life and health utilities in Australian patients with cirrhosis.

ABSTRACT:

Background and aim

Health-related quality-of-life measurements are important to understand lived experiences of patients who have cirrhosis. These measures also inform economic evaluations by modelling quality-adjusted life years (QALYs). We aimed to describe health-related quality of life, specifically multiattribute utility (scale anchors of death = 0.00 and full health = 1.00), across various stages and etiologies of cirrhosis.

Methods

Face-to-face interviews were used to collect Short Form 36 (SF-36) questionnaire responses from CirCare study participants with cirrhosis (June 2017 to December 2018). The severity of cirrhosis was assessed using the Child-Pugh score classified as class A (5-6 points), B (7-9), or C (10-15) and by the absence ("compensated") versus presence ("decompensated") of cirrhosis-related complications.

Results

Patients (n =?562, average 59.8?years [SD = 11.0], male 69.9%) had a range of primary etiologies (alcohol-related 35.2%, chronic hepatitis C 25.4%, non-alcoholic fatty liver disease (NAFLD) 25.1%, chronic hepatitis B 5.9%, "other" 8.4%). Significantly lower (all P versus compensated cirrhosis (mean = 0.68, SD = 0.12), Child-Pugh class C (mean = 0.59, SD = 0.15) or B (mean = 0.63, SD = 0.15) versus A (mean = 0.68, SD = 0.16), and between those of working age (18-64?years; mean = 0.64, SD = 0.16) versus those aged 65+ years (mean = 0.70, SD = 0.16). The greatest decrements in health-related quality of life relative to Australian population norms were observed across physical SF-36 domains.

Conclusions

Persons with more advanced cirrhosis report greater life impacts. Estimates from this study are suitable for informing economic evaluations, particularly cost-utility modelling, which captures the benefits of effective prevention, surveillance, and treatments on both the quality and quantity of patients' lives.

SUBMITTER: McPhail SM

PROVIDER: S-EPMC7812472 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature

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Publications

Assessment of health-related quality of life and health utilities in Australian patients with cirrhosis.

McPhail Steven M SM Amarasena Samath S Stuart Katherine A KA Hayward Kelly K Gupta Rohit R Brain David D Hartel Gunter G Rahman Tony T Clark Paul J PJ Bernardes Christina M CM Skoien Richard R Mckillen Benjamin B Lee Andrew A Pillay Leshni L Lin Lei L Khaing Myat Myat MM Horsfall Leigh L Powell Elizabeth E EE Valery Patricia C PC

JGH open : an open access journal of gastroenterology and hepatology 20201210 1

<h4>Background and aim</h4>Health-related quality-of-life measurements are important to understand lived experiences of patients who have cirrhosis. These measures also inform economic evaluations by modelling quality-adjusted life years (QALYs). We aimed to describe health-related quality of life, specifically multiattribute utility (scale anchors of death = 0.00 and full health = 1.00), across various stages and etiologies of cirrhosis.<h4>Methods</h4>Face-to-face interviews were used to colle ...[more]

PMID: 33490623

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Dataset Information

Assessment of health-related quality of life and health utilities in Australian patients with cirrhosis.

Background and aim

Methods

Results

Conclusions

Publications

Assessment of health-related quality of life and health utilities in Australian patients with cirrhosis.

Similar Datasets

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