Single nucleotide polymorphisms of insulin-like growth factor gene and mammographic breast density.

ABSTRACT:

Aim of the study

To analyze six single nucleotide polymorphisms (SNPs): rs1520220, rs2945834, rs5747694, rs6214, rs6219, rs5742678. An attempt was made to assess the significance of the above IGF-1 gene polymorphisms as prognostic and predictive factors in Polish women with diagnosed increased breast mammographic density.

Material and methods

The study included women diagnosed with an increased breast mammographic density (n = 98), breast cancer (n = 135) and women as a control group (n = 60). The method used to detect polymorphisms in the IGF-1 gene was the analysis of single-stranded DNA conformation polymorphism (SSCP-PCR) and Sanger's sequencing.

Results

In the case of rs1520220 polymorphism, the genotype CC was found to increase

SUBMITTER: Smolarz B 

PROVIDER: S-EPMC7812538 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature