Dataset Information
Dietary phenotype and advanced glycation end-products predict WTC-obstructive airways disease: a longitudinal observational study.
Ontology highlight
ABSTRACT: Background
Diet is a modifier of metabolic syndrome which in turn is associated with World Trade Center obstructive airways disease (WTC-OAD). We have designed this study to (1) assess the dietary phenotype (food types, physical activity, and dietary habits) of the Fire Department of New York (FDNY) WTC-Health Program (WTC-HP) cohort and (2) quantify the association of dietary quality and its advanced glycation end product (AGE) content with the development of WTC-OAD.Methods
WTC-OAD, defined as developing WTC-Lung Injury (WTC-LI; FEV1?ResultsN?=?9508 completed the annual questionnaire, while N?=?4015 completed REAP-S and had spirometry. WTC-OAD developed in N?=?921, while N?=?3094 never developed WTC-OAD. Low- and moderate-dietary quality, eating more (processed meats, fried foods, sugary drinks), fewer (vegetables, whole-grains),and having a diet abundant in AGEs were significantly associated with WTC-OAD. Smoking was not a significant risk factor of WTC-OAD.Conclusions
REAP-S was successfully implemented in the FDNY WTC-HP monitoring questionnaire and produced valuable dietary phenotyping. Our observational study has identified low dietary quality and AGE abundant dietary habits as risk factors for pulmonary disease in the context of WTC-exposure. Dietary phenotyping, not only focuses our metabolomic/biomarker profiling but also further informs future dietary interventions that may positively impact particulate matter associated lung disease.
SUBMITTER: Lam R
PROVIDER: S-EPMC7812653 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Publications
Dietary phenotype and advanced glycation end-products predict WTC-obstructive airways disease: a longitudinal observational study.
Respiratory research 20210118 1
<h4>Background</h4>Diet is a modifier of metabolic syndrome which in turn is associated with World Trade Center obstructive airways disease (WTC-OAD). We have designed this study to (1) assess the dietary phenotype (food types, physical activity, and dietary habits) of the Fire Department of New York (FDNY) WTC-Health Program (WTC-HP) cohort and (2) quantify the association of dietary quality and its advanced glycation end product (AGE) content with the development of WTC-OAD.<h4>Methods</h4>WTC ...[more]
