Ontology highlight
ABSTRACT:
SUBMITTER: Thota CK
PROVIDER: S-EPMC7812673 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Thota Chaitanya Kumar CK Mikolajczak Dorian J DJ Roth Christian C Koksch Beate B
ACS medicinal chemistry letters 20201214 1
Antibiotic-resistant microbes have become a global health threat. New delivery systems that enhance the efficacy of antibiotics and/or overcome the resistances can help combat them. In this context, we present <b>FF03</b>, a fibril-forming α-helical coiled-coil peptide that functions as an efficient scaffold for the multivalent presentation of the weakly cationic antimicrobial peptide (AMP) <b>IN4</b>. The resulting <b>IN4</b>-decorated <b>FF03</b> coiled-coil fibrils (<b>FF03 + IN4</b>) are non ...[more]