Diurnal rhythms across the human dorsal and ventral striatum.

ABSTRACT: The human striatum can be subdivided into the caudate, putamen, and nucleus accumbens (NAc). Each of these structures have some overlapping and some distinct functions related to motor control, cognitive processing, motivation, and reward. Previously, we used a "time-of-death" approach to identify diurnal rhythms in RNA transcripts in human cortical regions. Here, we identify molecular rhythms across the three striatal subregions collected from postmortem human brain tissue in subjects without psychiatric or neurological disorders. Core circadian clock genes are rhythmic across all three regions and show strong phase concordance across regions. However, the putamen contains a much larger number of significantly rhythmic transcripts than the other two regions. Moreover, there are many diffe

SUBMITTER: Ketchesin KD 

PROVIDER: S-EPMC7812799 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature